• Scientific Publications




    Ju-Yi Mao, Binesh Unnikrishnan, Han-Wei Chu, Scott G Harroun, Yet-Ran Chen, An-Tai Wu, Huan-Tsung Chang, Han-Jia Lin* and Chih-Ching Huang* (2021, Apr). Thermal-driven formation of polyphenolic carbonized nanogels with high anticoagulation activity from polysaccharides. Biomaterials science. Doi:10.1039/D1BM00402F.


    Chih-Yu Chung, Yu-Ju Chen, Chia-Hui Kang, Hung-Yun Lin, Chih-Ching Huang, Pang-Hung Hsu,* and Han-Jia Lin* (2021, May). Toxic or Not Toxic, That Is the Carbon Quantum Dot’s Question: A Comprehensive Evaluation with Zebrafish Embryo, Eleutheroembryo, and Adult Models. polymers, 13(10), 1598. Doi:10.3390/polym13101598


    Hung-Yun Lin, Sin-Wen Wang, Ju-Yi Mao, Huan-Tsung Chang, Scott G. Harroun, Han-Jia Lin*, Chih-Ching Huang and Jui-Yang Lai (2021, May). Carbonized nanogels for simultaneous antibacterial and antioxidant treatment of bacterial keratitis. Chemical Engineering Journal, 411, 128469. Doi:10.1016/j.cej.2021.128469


    Hao-Hsin Huang, Anisha Anand, Chin-Jung Lin, Han-Jia Lin, Yang-Wei Lin, Scott G. Harroun and, Chih-Ching Huang (2021, Apr). LED irradiation of halogen/nitrogen-doped polymeric graphene quantum dots triggers the photodynamic inactivation of bacteria in infected wounds. Carbon, 174, 710- 722. Doi:10.1016/j.carbon.2020.11.092




    Shou-Kuan Tsai, Cheng-Hsin Shih, Hui-Wen Chang, Kuang-Huan Teng, Wei-En Hsu, Han-Jia Lin, Han-You Lin, Ching-Huei Huang, Hui-Wen Chen and Lih- Chiann Wang (2020, Jun): Replication of a Dog-Origin H6N1 Influenza Virus in Cell Culture and Mice. Viruses, 12, 704. DOI:10.3390/v12070704


    Hung-Yun Lin, Wei-Yu Yeh, Sheng-Fang Tsai, Kuo-Ping Chiang, John Han-You Lin, Che-Chia Tsao* and Han-Jia Lin* (2020, May): Biological protective effects against Vibrio infections in grouper larvae using the Strombidium sp. NTOU1, a marine ciliate amenable for scaled-up culture and with an excellent bacteriovorous ability. Frontiers in Marine Science, 7, 373. DOI:10.3389/fmars.2020.00373


    Huai-ting Huang, Han-Jia Lin, Hui-Ju Huang, Chih-ching Huang, John Han-You Lin and Li-Li chen (2020, Apr). Synthesis and evaluation of polyamine carbon quantum dots (cQDs) in Litopenaeus vannamei as a therapeutic agent against WSSV. Scientific Reports, 10:7343. DOI:10.1038/s41598-020-64325-5


    Shou-Kuan Tsai, Chen-Chih Chen, Han-Jia Lin, Han-You Lin, Ting-Tzu Chen, and Lih-Chiann Wang (2020, Mar). Combination of multiplex reverse transcription recombinase polymerase amplification assay and capillary electrophoresis provides high sensitive and high-throughput simultaneous detection of avian influenza virus subtypes. Journal of Veterinary Science, 21, e24. (SCI). DOI:10.4142/jvs.2020.21.e24 .


    Hong-Jyuan Jian, Jiantao Yu, Yu-Jia Li, Binesh Unnikrishnan Yu-Fen Huang, Li- Jyuan Luo, David Hui-Kang Ma, Scott G. Harroun, Huan-Tsung Chang, Han-Jia Lin, Jui-Yang Lai, Chih-Ching Huang (2020, Jan). Highly adhesive carbon quantum dots from biogenic amines for prevention of biofilm formation. Chemical Engineering Journal. 386, 123913 DOI:10.1016/j.cej.2019.123913.DOI:10.1016/j.cej.2019.123913.



    Chin-Jung Lin, Lung Chang, Han-Wei Chu, Han-Jia Lin, Pei-Ching Chang, Robert Y. L. Wang,* Binesh Unnikrishnan, Ju-Yi Mao, Shiow-Yi Chen,* and Chih-Ching Huang* (2019, Aug). High Amplification of the Antiviral Activity of Curcumin through Transformation into Carbon Quantum Dots . small, 15(41), 1902641. DOI:10.1002/smll.201902641


    Ju-Yi Mao, Fu-Yin Lin, Han-Wei Chu, Scott G. Harroun, Jui-Yang Lai, Han-Jia Lin*, Chih-Ching Huang*: In situ synthesis of core-shell carbon nanowires as a potent targeted anticoagulant. Journal of Colloid and Interface Science 05/2019; 552., DOI:10.1016/j.jcis.2019.05.086


    A. Venerando, M. Magro, D. Baratella, J. Ugolotti, S. Zanin, O. Malina, R. Zboril, H. Lin, F. Vianello. Biotechnological applications of nanostructured hybrids of polyamine carbon quantum dots and iron oxide nanoparticles. Amino Acids 04/2019 https://doi.org/10.1007/s00726-019-02721-6


    Hung-Yun Lin, Han-Jia Lin*: Polyamines in Microalgae: Something Borrowed, Something New. Marine Drugs 01/2019; 17(1):1.,http://DOI:10.3390/md17010001


    Tun-Wen Pai, Kuan-Hung Li, Cing-Han Yang, Chin-Hwa Hu, Han-Jia Lin, Wen-Der Wang, Yet-Ran Chen: Multiple model species selection for transcriptomics analysis of non-model organisms. BMC Bioinformatics 08/2018; 19(S9):137-150., DOI:10.1186/s12859-018-2278-z


    Po-Chih Kuo, Chia-Wen Lien, Ju-Yi Mao, Binesh Unnikrishnan, Huan-Tsung Chang, Han-Jia Lin*, Chih-Ching Huang*: Detection of urinary spermine by using silver-gold/silver chloride nanozymes. Analytica Chimica Acta 06/2018; 1009., DOI:10.1016/j.aca.2018.01.018


    Anisha Anand, Binesh Unnikrishnan, J.-Y. Mao, H.-J. Lin*, C.-C. Huang*: Graphene-based nanofiltration membranes for improving salt rejection, water flux and antifouling–A review. Desalination 03/2018; 429:119-133., DOI:10.1016/j.desal.2017.12.012


    Ju-Yi Mao, Han-Wei Li, Shih-Chun Wei, Scott G. Harroun, Ming-Ying Lee, Hung-Yun Lin, Chih-Yu Chung, Chun-Hua Hsu, Yet-Ran Chen, Han-Jia Lin*, Chih-Ching Huang*: DNA Modulates the Interaction of Genetically Engineered DNA-Binding Proteins and Gold Nanoparticles: Diagnosis of High-Risk HPV Infection. ACS Applied Materials & Interfaces 12/2017; 9(51)., DOI:10.1021/acsami.7b13873


    Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang, Shou-Kuan Tsai, Han-Jia Lin*: Reborn from the Ashes: Turning Organic Molecules to Antimicrobial Carbon Quantum Dots. 09/2017; 3(11)., DOI:10.1021/acsinfecdis.7b00150


    Hong-Jyuan Jian, Ren-Siang Wu, Tzu-Yu Lin, Yu-Jia Li, Han-Jia Lin, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang: Super-Cationic Carbon Quantum Dots Synthesized from Spermidine as an Eye Drop Formulation for Topical Treatment of Bacterial Keratitis. ACS Nano 07/2017; 11(7)., DOI:10.1021/acsnano.7b01023


    Hung-Yun Lin, Shao-Chieh Yen, Po-Chih Kuo, Chih-Yu Chung, Kuan-Lin Yeh, Ching-Huei Huang, Jeng Chang, Han-Jia Lin*: Alkaline phosphatase promoter as an efficient driving element for exogenic recombinant in the marine diatom Phaeodactylum tricornutum. Algal Research 04/2017; 23:58-65., DOI:10.1016/j.algal.2017.01.007


    Pei-Xin Lai, Chung-Wein Chen, Shih-Chun Wei, Tzu-Yu Lin, Hong-Jyuan Jian, Irving Po-Jung Lai, Ju-Yi Mao, Pang-Hung Hsu, Han-Jia Lin, Wen-Shyong Tzou, Shiow-Yi Chen, Scott G. Harroun, Jui-Yang Lai, Chih-Ching Huang: Ultrastrong Trapping of VEGF by Graphene Oxide: Anti-angiogenesis Application. Biomaterials 09/2016; 109., DOI:10.1016/j.biomaterials.2016.09.005


    Yu-Jia Li, Scott G. Harroun, Yu-Chia Su, Chun-Fang Huang, Binesh Unnikrishnan, Han-Jia Lin*, Chia-Hua Lin, Chih-Ching Huang*: Synthesis of Self-Assembled Spermidine-Carbon Quantum Dots Effective against Multidrug-Resistant Bacteria. Advanced Healthcare Materials 07/2016; 5(19)., DOI:10.1002/adhm.201600297


    Chi-Fu Chou, Han-Jia Lin, Chih-Yu Tsai, Tzung-Yi Lin, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou: Hypoxia-inducible factor 2-alpha participates in the regulation of intersegmental vessels angiogenesis and neuromast deposition. Journal of Marine Science and Technology 04/2016; 24(2):347-358., DOI:10.6119/JMST-015-0629-1


    San-Shan Huang, Shih-Chun Wei, Huan-Tsung Chang, Han-Jia Lin, Chih-Ching Huang: Gold nanoparticles modified with self-assembled hybrid monolayer of triblock aptamers as a photoreversible anticoagulant. Journal of Controlled Release 11/2015; 221., DOI:10.1016/j.jconrel.2015.11.028


    Han-Jia Lin, Yu-Jia Li, Chih-Ching Huang: Use of polyamine to synthesize fluorescent carbon quantum dots as bactericide and transfection reagents. Amino Acids 08/2015; 47(8):1670-1670.


    Wei-Jane Chiu, Tsung-Kai Ling, Hai-Pang Chiang, Han-Jia Lin, Chih-Ching Huang: Monitoring Cluster Ions Derived from Aptamer-Modified Gold Nanofilms under Laser Desorption/Ionization for the Detection of Circulating Tumor Cells. ACS Applied Materials & Interfaces 04/2015; 7(16)., DOI:10.1021/acsami.5b00731


    Ka-Lai Pang, Han-Jia Lin, Hung-Yun Lin, Yu-Fen Huang, Yi-Min Chen: Production of Arachidonic and Eicosapentaenoic Acids by the Marine Oomycete Halophytophthora. Marine Biotechnology 08/2014; 17(2)., DOI:10.1007/s10126-014-9600-1


    Tzung-Yi Lin, Chi-Fu Chou, Hsin-Yu Chung, Chia-Yin Chiang, Chung-Hao Li, Jen-Leih Wu, Han-Jia Lin, Tun-Wen Pai, Chin-Hwa Hu, Wen-Shyong Tzou: Hypoxia-Inducible Factor 2 Alpha Is Essential for Hepatic Outgrowth and Functions via the Regulation of leg1 Transcription in the Zebrafish Embryo. PLoS ONE 07/2014; 9(7):e101980., DOI:10.1371/journal.pone.0101980


    Wen-Shyong Tzou, Ying Chu, Tzung-Yi Lin, Chin-Hwa Hu, Tun-Wen Pai, Hsin-Fu Liu, Han-Jia Lin, Ildeofonso Cases, Ana Rojas, Mayka Sanchez, Zong-Ye You, Ming-Wei Hsu: Molecular Evolution of Multiple-Level Control of Heme Biosynthesis Pathway in Animal Kingdom. PLoS ONE 01/2014; 9(1):e86718., DOI:10.1371/journal.pone.0086718


    Yen-Chun Shiang, Chung-Mao Ou, Shih-Ju Chen, Ting-Yu Ou, Han-Jia Lin*, Chih-Ching Huang, Huan-Tsung Chang*: Highly efficient inhibition of human immunodeficiency virus type 1 reverse transcriptase by aptamers functionalized gold nanoparticles. Nanoscale 02/2013; 5(7)., DOI:10.1039/c3nr33403a


    Hung-Yun Lin, Chi-Yu Shih, Hung-Chun Liu, Jeng Chang, Ying-Lan Chen, Yet-Ran Chen, Han-Tso Lin, Yu-Yung Chang, Chun-Hua Hsu, Han-Jia Lin*: Identification and Characterization of an Extracellular Alkaline Phosphatase in the Marine Diatom Phaeodactylum tricornutum. Marine Biotechnology 01/2013; 15(4)., DOI:10.1007/s10126-013-9494-3


    Yi-Chin Lien, Ting-Yu Ou, Yu-Tzu Lin, Po-Chih Kuo, Han-Jia Lin*: Duplication and Diversification of the Spermidine/Spermine N-acetyltransferase 1 Genes in Zebrafish. PLoS ONE 01/2013; 8(1):e54017., DOI:10.1371/journal.pone.0054017


    Li-Yi Chen, Chih-Ching Huang, Wei-Yu Chen, Han-Jia Lin, Huan-Tsung Chang: Using photoluminescent gold nanodots to detect hemoglobin in diluted blood samples. Biosensors & Bioelectronics 12/2012; 43C(1):38-44., DOI:10.1016/j.bios.2012.11.034


    Huan-Chin Tseng, Jyh-Bing Tang, P S Sudhakar Gandhi, Ching-Wei Luo, Chung-Mao Ou, Chia-Jen Tseng, Han-Jia Lin*, Yee-Hsiung Chen: Mutual adaptation between mouse transglutaminase 4 and its native substrates in the formation of copulatory plug. Amino Acids 08/2011; 42(2-3):951-60., DOI:10.1007/s00726-011-1009-9


    Han-Jia Lin*, Yi-Chin Lien, Chun-Hua Hsu: A high-throughput colorimetric assay to characterize the enzyme kinetic and cellular activity of spermidine/spermine N1-acetyltransferase 1. Analytical Biochemistry 12/2010; 407(2):226-32., DOI:10.1016/j.ab.2010.07.036


    Chao-Jung Chen, Mei-Chun Tseng, Han-Jia Lin, Ting-Wei Lin, Yet-Ran Chen: Visual Indicator for Surfactant Abundance in MS-Based Membrane and General Proteomics Applications. Analytical Chemistry 10/2010; 82(19):8283-90., DOI:10.1021/ac1017937


    Hui-Chung Wu, Tzu-Ning Chen, Shao-Hsuan Kao, Hao-Ai Shui, Wei-Jung Chen, Han-Jia Lin, Han-Min Chen: Isoelectric Focusing Management: An Investigation for Salt Interference and an Algorithm for Optimization. Journal of Proteome Research 09/2010; 9(11):5542-56., DOI:10.1021/pr1008256


    Chung-Mao Ou, Shih-Ren Lin, Han-Jia Lin, Ching-Wei Luo, Yee-Hsiung Chen: Exclusive Expression of a Membrane-Bound Spink3-Interacting Serine Protease-Like Protein TESPL in Mouse Testis. Journal of Cellular Biochemistry 06/2010; 110(3):620-9., DOI:10.1002/jcb.22571


    Cheng-Kang Chiang, Zusing Yang, Yang-Wei Lin, Wen-Tsen Chen, Han-Jia Lin, Huan-Tsung Chang: Detection of Proteins and Protein-Ligand Complexes Using HgTe Nanostructure Matrixes in Surface-Assisted Laser Desorption/Ionization Mass Spectrometry. Analytical Chemistry 06/2010; 82(11):4543-50., DOI:10.1021/ac100550c


    Huan-Chin Tseng, Han-Jia Lin, Jyh-Bing Tang, P.S. Sudhakar Gandhi, Wei-Chao Chang, Yee-Hsiung Chen: Identification of the Major TG(4) Cross-Linking Sites in the Androgen-Dependent SVS I Exclusively Expressed in Mouse Seminal Vesicle. Journal of Cellular Biochemistry 08/2009; 107(5):899-907., DOI:10.1002/jcb.22190


    Huan-Chin Tseng, Han-Jia Lin, P. S. Sudhakar Gandhi, Chia-Yih Wang, Yee-Hsiung Chen: Purification and identification of transglutaminase from mouse coagulating gland and its cross-linking activity among seminal vesicle secretion proteins. Journal of Chromatography B 11/2008; 876(2):198-202., DOI:10.1016/j.jchromb.2008.10.041


    Yee-Hsiung Chen, Huan-Chin Tseng, Han-Jia Lin, Chia-Yih Wang: An Interlocking Meshwork of Covalent Cross-Links between SVS I-III from the Mouse SeminalVesicle are involved in Copulatory Plug Formation. Biology of Reproduction 05/2008; 78(Suppl_1):220-220., DOI:10.1093/biolreprod/78.s1.220a


    Han-Jia Lin, Ching-Wei Luo, Chia-Yih Wang, Yee-Hsiung Chen: Epitope topology and removal of mouse acrosomal plasma membrane by P12-targeted immunoaggregation. Biochemical and Biophysical Research Communications 11/2006; 349(1):284-8., DOI:10.1016/j.bbrc.2006.08.045


    Han-Jia Lin, Chun-Hui Lin, Huan-Chin Tseng, Yee-Hsiung Chen: Detecting disulfide crosslinks of high-molecular weight complexes in mouse SVS proteins by diagonal electrophoresis. Analytical Biochemistry 06/2006; 352(2):296-8., DOI:10.1016/j.ab.2006.03.005


    HJ Lin, CH Lin, HC Tseng, YH Chen: Detecting disulfide crosslinks of high-molecular weight complexes in mouse SVS proteins by diagonal electrophoresis. Analytical Biochemistry 05/2006; 352(2):296-298., DOI:10.1016/j.sb.2006.03.005


    Han-Jia Lin, Chin-Mei Lee, Ching-Wei Luo, Yee-Hsiung Chen: Functional preservation of duplicated pair for RSVS III gene in the REST locus of rat 3q42. Biochemical and Biophysical Research Communications 02/2005; 326(2):355-63., DOI:10.1016/j.bbrc.2004.11.030


    Ching-Wei Luo, Han-Jia Lin, S C B Gopinath, Yee-Hsiung Chen: Distinction of Sperm-Binding Site and Reactive Site for Trypsin Inhibition on P12 Secreted from the Accessory Sex Glands of Male Mice. Biology of Reproduction 05/2004; 70(4):965-71., DOI:10.1095/biolreprod.103.020552


    Han-Jia Lin, Ching-Wei Luo, Yee-Hsiung Chen: Localization of the Transglutaminase Cross-linking Site in SVS III, a Novel Glycoprotein Secreted from Mouse Seminal Vesicle. Journal of Biological Chemistry 03/2002; 277(5):3632-9., DOI:10.1074/jbc.M107578200


    C W Luo, H J Lin, YH Chen: A Novel Heat-labile Phospholipid-binding Protein, SVS VII, in Mouse Seminal Vesicle as a Sperm Motility Enhancer. Journal of Biological Chemistry 04/2001; 276(10):6913-21., DOI:10.1074/jbc.M006954200


    S T Chu, H J Lin, H L Huang, YH Chen: The hydrophobic pocket of 24p3 protein from mouse uterine luminal fluid: Fatty acid and retinol binding activity and predicted structural similarity to lipocalins. Journal of Peptide Research 12/1998; 52(5):390-7., DOI:10.1111/j.1399-3011.1998.tb00663.x


    SIN‐TAK CHU, HAN‐JIA LIN, YEE‐HSIUNG CHEN: Complex formation between a formyl peptide and 24p3 protein with a blocked N-terminus of pyroglutamate. European Journal of Peptide Research 07/1997; 49(6):582-5., DOI:10.1111/j.1399-3011.1997.tb01166.x

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